Method of preparing 9-amino-1,2,3,4,-tetrahydroacridin-1-ones an

Details Method of preparing 9-amino-1,2,3,4,-tetrahydroacridin-1-ones an Method of preparing 9-amino-1,2,3,4,-tetrahydroacridin-1-ones an

Filed on

1987-11-25

Date issued

1989-05-30

Examiner

Sutto, Anton H.

Patent Class

Organic compounds -- part of the class 532-570 series

SubClass

Organic compounds

SubSubClass

Heterocyclic carbon compounds containing a hetero ring...

Other Related Categories

546 93, 546105, C07D22106, C07D21910

Type

Patent

Status

active

Patent number

048352756

Description

ABSTRACT:
There are disclosed compounds having the formula ##STR1## wherein n is 1, 2 or 3; X is hydrogen, loweralkyl, loweralkoxy, halogen, hydroxy, nitro, trifluoromethyl, NHCOR.sub.2 where R.sub.2 is loweralkyl, or NR.sub.3 R.sub.4 where R.sub.3 and R.sub.4 are independently hydrogen or loweralkyl; R is hydrogen or loweralkyl; R.sub.1 is hydrogen, loweralkyl, diloweralkylaminoloweralkyl, arylloweralkyl, diarylloweralkyl, furylloweralkyl, thienylloweralkyl, oxygen-bridged arylloweralkyl, oxygen-bridged diarylloweralkyl, oxygen-bridged furylloweralkyl or oxygen-bridged thienylloweralkyl; Y is C.dbd.O or CR.sub.5 OH where R.sub.5 is hydrogen or loweralkyl; Z is CH.sub.2 or C.dbd.CR.sub.6 R.sub.7 where R.sub.6 and R.sub.7 are independently hydrogen or loweralkyl; or Y and Z taken together is CR.sub.5 .dbd.CH where CR.sub.5 and CH correspond to Y and Z respectively; an optical antipode thereof, or a pharmaceutically acceptable acid addition salt thereof, which are useful for enhancing memory, methods for synthesizing them, and pharmaceutical compositions comprising an effective memory enhancing amount of such a compound.

REFERENCES:
patent: 3580915 (1971-05-01), Wolf et al.
patent: 3947449 (1976-03-01), Durckheimer et al.
patent: 3987047 (1976-10-01), Griss et al.
patent: 4550113 (1985-10-01), Lavretskaya et al.
Moore et al., Chemical Abstracts, vol. 59:15256g-15257c (1963).
Albert, "The Acridines", 2nd ed., New York, St. Martins Press, 1966, pp. 46-47, 570.
Konshin et al., (T), Chemical Abstracts, vol. 76: 34080k (1972).

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