Mass spectrometry method using time-varying filtered noise

Details Mass spectrometry method using time-varying filtered noise Mass spectrometry method using time-varying filtered noise

1991-11-06

1993-02-16

Berman, Jack I.

Radiant energy

Ionic separation or analysis

Methods

250290, 250292, H01J 4942

Patent

active

051873656

ABSTRACT:
A method for performing mass analysis with dynamic mass resolution, in which a time-varying notch filtered broadband voltage signal (sometimes denoted as a time-varying "filtered noise" signal) is applied to a quadrupole mass filter. The time-varying filtered noise signal can consist of a rapid sequence of static (time-invariant) filtered noise signals, each defining a notch having a selected width and center location. The invention facilitates performance of mass analysis over a wide range of ion mass-to-charge ratios ("mass ranges") with adequate mass resolution. By appropriately choosing the width of each notch in the applied time-varying filtered noise, mass analysis can be performed with substantially constant mass separation over a wide mass range. In order to maintain substantially constant mass separation while analyzing a selected consecutive or non-consecutive sequence of ions (by passing such sequence of ions through the mass filter), the applied filtered noise should have narrower notches at times when ions with higher mass-to-charge ratio are to be selected, and wider notches at times when ions with lower mass-to-charge ratio are to be selected.

REFERENCES:
patent: 3334225 (1967-08-01), Langmuir
patent: 4736101 (1988-04-01), Syka et al.
patent: 4761545 (1988-08-01), Marshall et al.
patent: 5075547 (1991-12-01), Johnson et al.
patent: 5134286 (1992-07-01), Kelley
Extension of Dynamic Range in Fourier Transform Ion Cyclotron Resonance Mass Spectrometry via Stored Waveform Inverse Fourier Transform Excitation, Tao-Chin Lin Wang, Tom L. Ricca & Alan Marshall, Anal. Chem., 1986 5B, 2935-2938.

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