Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Patent
1986-09-29
1993-02-16
Brust, Joseph Paul
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
546147, 546256, 546268, 546278, 546281, 546323, 546335, 548201, 5483151, 5483794, 548452, 548482, 548491, 548495, 548515, 548517, 548527, 548533, 5483121, 5483127, 5483154, 5483131, 558240, 560 27, 560 28, 560 32, 560 33, C07D20709, C07D20912, C07D21316, C07D, C07D
Patent
active
051872900
ABSTRACT:
Compounds of the formula ##STR1## wherein Z is oxygen or sulfur are disclosed. These compounds are useful as hypotensive agents due to their angiotensin converting enzyme inbitition activity and depending upon the definition of X may also be useful as analgesics due to their enkephalinase inhibition activity.
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patent: 4636522 (1987-01-01), Gordon
Meyer et al., "Novel Synthesis of . . . "J. Med. Chem. (1981), vol. 24, pp. 964-969.
Almquist et al., "Derivatives of Potent Angiotensin Converting Enzyme Inhibitor . . . ", J. Med. Chem., (1982) vol. 25, 1292-1299.
Brust Joseph Paul
Davis Stephen B.
E. R. Squibb & Sons Inc.
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