N-phenyl-N'-benzothienylmethyl-bis-diamino-5-methylene-1,3-diox

Details N-phenyl-N'-benzothienylmethyl-bis-diamino-5-methylene-1,3-diox N-phenyl-N'-benzothienylmethyl-bis-diamino-5-methylene-1,3-diox

1992-07-22

1993-02-16

Raymond, Richard L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

549 51, 549 57, C07D33356

Patent

active

051872846

ABSTRACT:
A compound of the formula: ##STR1## in which X, Y and Z are, independently, hydrogen, halogen, hydroxy, nitro, cyano, carboxyl, trifluoromethyl, phenyl, amino, alkylamino, dialkylamino, alkyl or alkoxy; R.sub.1 is hydrogen, alkyl, alkenyl, cycloalkyl, phenyl, benzyl or substituted phenyl or benzyl or alkoxy; or a pharmaceutically acceptable salt thereof are ACAT inhibitors.

REFERENCES:
patent: 4387105 (1983-06-01), De Vries et al.
patent: 4387106 (1983-06-01), De Vries et al.
DeVries et al. J. Med. Chem. 29, 1131 (1986).
Ross et al., The Journal of Biological Chemistry, 259(2), pp. 815-819 (1984).
Brown et al, The Journal of Biological Chemistry, 255(19), pp. 9344-9352 (1980).
Stephen, Monat, Fur Chemie, 97, 45 (1966).
Derwent Abstract 40365K, abstract of JP 58-046084 (1983).
Augustin et al., Z. Chem. 30, 169 (1990).
Augustin et al. Wiss. Univ. Halle XXXVIII 1989 M, H.3, 527-36.
Ye et al. Synthesis, pp. 317-320 (1989).
Chem. Abstract 72(23) 112900 (1969).

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