Microorganisms useful in the process for the production of l-car

Details Microorganisms useful in the process for the production of l-car Microorganisms useful in the process for the production of l-car

1990-03-15

1993-02-16

Raymond, Richard L.

Chemistry: molecular biology and microbiology

Micro-organism, per se ; compositions thereof; proces of...

Bacteria or actinomycetales; media therefor

435128, 4352533, 435824, C12N 112, C12N 120

Patent

active

051870932

ABSTRACT:
Process for the production of L-carnitine utilizing a microorganism. The microorganism is cultivated with crotonobetaine and/or .gamma.-butyrobetaine in the presence of a growth substrate. The enriched L-carnitine is isolated. The microorganisms used are those which are capable of producing L-carnitine while not catabolizing it from crotonobetaine and/or .gamma.-butyrobetaine. The microorganisms can be obtained by the following selection method. Microorganisms which grow with betaine, .gamma.-butyrobetaine, crotonobetaine and L-carnitine as the C- and N-source are mutated in the conventional manner. From the culture obtained by cultivating of the mutated microorganisms, those microorganisms are selected which are stable, do not catabolize L-carnitine and do not grow on L-carnitine, crotonobetaine and .gamma.-butyrobetaine, but grow with betaine.

REFERENCES:
patent: 2313573 (1943-03-01), Orthner et al.
patent: 2367878 (1945-01-01), Lee
patent: 3466364 (1969-09-01), Takahashi et al.
patent: 3711549 (1973-01-01), Phillips et al.
patent: 3796632 (1974-03-01), Fukumura
patent: 4371618 (1983-02-01), Cavazza
patent: 4567140 (1986-01-01), Voelskow et al.
patent: 4650759 (1987-03-01), Yokzeki et al.
patent: 4708936 (1987-11-01), Kulla et al.
patent: 4806282 (1989-02-01), Tiuti et al.
Miller, Experiments in Molecular Genetics, (1972), pp. 121-180.
Oraston et al., Biochemical and Biophysical Research, vol. 36, No. 1, (1969), pp. 179-184.
Perry's Chemical Engineer's Handbook, 6th Edition, (1984), p. 27-7.
Askens et al., J. Chem. Soc., pp. 103ff (1959).
Miller, J. H., "Experiments in Molecular Genetics", Cold Spring Laboratory, (1972), pp. 121 to 179.
Gerhardt, P. "Manual of Methods for General Bacteriology", Am. Soc. for Microbiology (1981), pp. 222 to 242.
Ornston, L. N., et al., Biochem. Biophys. Res. Commun. 35 (1969) pp. 179 to 184.
Vandecasteele, J. P., Applied Environ. Microbiol. 39, (1980), pp. 327 to 334.
Kulla H. G., et al., Arch. Microbiol. 135, (1983), pp. 1 to 7.
G. Lindstedt et al., Biochemisrty, 6, 1967, pp. 1262-1270.
G. Lindstedt et al., Biochemistry 16, 1977, pp. 2181-2188.
Seim et al., Eur. Cong. Biotechnol., 3rd, vol. 1, 481-6 (1984).

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