Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1989-12-22
1993-02-16
Kepplinger, Esther L.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
435 792, 435961, 436507, 530868, 530412, 530421, G01N 33569, G01N 33564
Patent
active
051870657
ABSTRACT:
A method for detecting the onset or presence of Lyme disease in a mammal, which comprises isolating a biological sample from the mammal, isolating from said biological sample any circulating immune complexes suspected to contain antibody reactive to Borrelia burgdorferi, dissociating the immune complexes so isolated, and examining the dissociated immune complexes for the presence of antibody. The present method offers a simple and reliable means for detecting Borrelia antibodies. Test kits and related methodology are also disclosed.
REFERENCES:
patent: 4459359 (1984-07-01), Neurath
patent: 4548908 (1985-10-01), Kameda
Dattwyler et al. "Seronegative Lyme Disease" New England Journal of Medicine 319(22) pp. 1441-1446 (Dec. 1, 1988).
Jones et al., "Isolation of Immune Complexes and Characterisation of their Constituent Antigens and Antibodies in some Human Diseases: A Review" J. Immunol. Methods 44 pp 219-270 (1981).
Allen C. Steere, "Pathogenesis of Lyme Disease, Implications for Rheumatic Disease," Annals New York Academy of Sciences, vol. 539 (1988), 87-92.
Hardin et al., "Immune Complexes & The Evolution of Lyme Arthritis," N. Eng. J. of Med., vol. 301, No. 25 (1979), 1358-1363.
Coyle et al., "Multiple Sclerosis Immune Complexes: An Analysis of Component Antigents & Antibodies," Annals of Neurology, vol. 16, No. 6 (1984), 660-667.
Volkman & Dattwyler, "Immunogiagnosis & Treatment of Lyme Borreliosis," Medical Times, vol. 11, No. 8 (1989), 59-71.
Trock & Craft, "Lyme Disease: A Clinical Perspective," Medical Times, vol. 117, No. 3 (1989), 56-65.
Alan G. Barbour, "The Diagnosis of Lyme Disease: Rewards & Perils," Annals of Internal Medicine, vol. 110, No. 7 (1989), 501-502.
Frederick W. Hyde et al., "Detection of Antigens in Urine of Mice & Humans Infected with Borrelia burgdorferi," J. Clinical Microbiology (1989), 58-61.
Allen C. Steere, "Medical Progress, Lyme Disease," N. Eng. J. of Med., vol. 321, No. 9 (1989), 586-596.
Burke A. Cunha, "The Many Manifestations of Lyme Disease," Emergency Medicine, (Feb. 15, 1989), 55-71.
"Bad News Regarding Early Detection of Lyme Disease," Internal Medicine News, vol. 23, No. 12, Jun. 15-30, 1989.
Clark, Jennifer, "Lyme Disease: Early Diagnosis is Imperative to Avoid Serious Late-Stage Complications," Modern Med., vol. 57, No. 6 (Jun., 1989).
Joseph E. Craft et al., "Antibody Response in Lyme Disease, Evaluation of Diagnostic Tests," J. Infec. Dis., vol. 149, No. 5, (May, 1984), 789-795.
Klaus Hoffken et al., "Dissocation & Isolation of Antigen & Antibody from Immune Complexes," J. Immun. Methods, vol. 53 (1982), 51-59.
Louis A. Magnarelli et al., "Enzyme-Linked Immunosorbent Assays for Lyme Disease," J. Infec. Dis., vol. 159, No. 1 (Jan., 1989), 43-48.
M. Digeon et al., "Detection of Circulating Immune Complexes in Human Sera Etc.," J. Immunological Methods, vol. 16 (1977), 165-183.
Bidwell Carol E.
Kepplinger Esther L.
LandOfFree
Method and materials for detecting lyme disease does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method and materials for detecting lyme disease, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method and materials for detecting lyme disease will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2147660