Compounds useful as antiproliferative agents and GARFT inhibitor

Details Compounds useful as antiproliferative agents and GARFT inhibitor Compounds useful as antiproliferative agents and GARFT inhibitor

1994-07-28

1997-03-04

Grumbling, Matthew V.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

549 73, C07D33310, C07D33322

Patent

active

056080824

ABSTRACT:
Compounds of the Formula I, which are in equilibrium with their 4-hydroxy tautomers and are in the form of diastereomeric mixtures, and their pharmaceutically acceptable salts are potent GARFT inhibitors: ##STR1## wherein A, Z, X, and R.sub.1 and R.sub.2 are defined in the specification. These compounds and their salts are useful as antiproliferative agents. The invention also pertains to pharmaceutical compositions and methods employing such compounds as GARFT inhibitors or antiproliferative agents. The invention also relates to compounds useful as intermediates for preparing such compounds, and to their synthesis.

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