Topical alkyl-2-O-L-ascorbyl-phosphates

Details Topical alkyl-2-O-L-ascorbyl-phosphates Topical alkyl-2-O-L-ascorbyl-phosphates

1995-06-07

1997-03-04

Nutter, Nathan M.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514844, 514847, 424401, 549315, A01N 4308, A61K 3134

Patent

active

056079680

ABSTRACT:
This disclosure relates to a method for topical use of a derivative of L-ascorbic acid which is stable, easily incorporated into cosmetically acceptable vehicles and enzymatically bioreversible in the skin to free ascorbic acid and a safe alkanol component. An exemplary embodiment uses the alkyl-2-O-L-ascorbyl-phosphate which is shown in Formula I. ##STR1##

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Steinhart et al., Pro-and Antioxidative Effect of Ascorbic Acid on L-Tryptophan in the System Fe.sup.3+ /Ascorbic Acid/O.sub.2, J. Agric. Food Chem., vol. 41, pp. 2275-2277 (1993).
Sakamoto et al., Measurement Method of Efficacy of Antidandruff Cosmetics and Development of the New Active Commercial Product, IFSCC, Yokohama, vol. B206, pp. 823-864 (1993).

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