Antidepressant 3-(aminocycloalkenyl)-indole-5-nitrile derivative

Details Antidepressant 3-(aminocycloalkenyl)-indole-5-nitrile derivative Antidepressant 3-(aminocycloalkenyl)-indole-5-nitrile derivative

1995-08-22

1997-03-04

Jordan, Charles T.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

548503, 548504, 548454, A61K 31405

Patent

active

056079613

ABSTRACT:
Certain 3-amino-cycloalkanyl and cycloalkenyl derivatives of 5-cyano-substituted indoles of Formula I are useful antidepressant agents. ##STR1## The substituent R.sup.1 is hydrogen or C.sub.1-4 alkyl and R.sup.2 is C.sub.1-4 alkyl or --(CH.sub.2).sub.p --Ar with Ar being a phenyl, pyridinyl, pyrimidinyl or 1,4-benzodioxan-2-yl moiety. The symbol m is zero or 1, n is 1 to 3 and p is zero or 1 to 4.

REFERENCES:
patent: 4954502 (1990-09-01), Smith et al.
patent: 5124332 (1992-06-01), Wise et al.
patent: 5245046 (1993-09-01), Youngdale et al.
patent: 5468768 (1995-11-01), Cipollina et al.

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