Barrier-controlled assay device

Details Barrier-controlled assay device Barrier-controlled assay device

1993-12-07

1997-03-04

Housel, James C.

Chemistry: analytical and immunological testing

Involving an insoluble carrier for immobilizing immunochemicals

422 56, 422 57, 422 58, 422 61, 422104, 435 792, 435 793, 435 794, 435805, 435969, 435970, 436165, 436170, 436514, 436810, G01N 33543, G01N 33558

Patent

active

056078633

ABSTRACT:
An assay device for detection and/or determination of an analyte in a test sample uses a barrier containing an aperture to control the application of reagents to the device for greater reproducibility of results. In its simplest form, the device comprises: (1) a chromatographic medium having a first end, a second end, and first and second surfaces, and having a specific binding partner for the analyte immobilized thereto in a detection zone; (2) at least one absorber in operable contact with at least one of the first and second ends; and (3) a substantially fluid-impermeable barrier adjacent to the first surface of the chromatographic medium, the barrier having at least one aperture therethrough for application of liquid to the chromatographic medium, the barrier at least partially blocking application of liquid to the chromatographic medium. The device can be adapted for sandwich or competitive assays and can be used to perform amplified assays, such as those using silver amplification or enzyme amplification. Various arrangements of components within the device are possible, and elements such as filters can be accommodated.

REFERENCES:
patent: 3723064 (1973-03-01), Liotta
patent: 3798004 (1974-03-01), Zerachia et al.
patent: 3888629 (1975-06-01), Bagshawe
patent: 3915647 (1975-10-01), Wright
patent: 3933594 (1976-01-01), Milligan
patent: 3966897 (1976-06-01), Renn et al.
patent: 3985867 (1976-10-01), Redshaw
patent: 3990850 (1976-11-01), Friedman et al.
patent: 3993451 (1976-11-01), Verbeck
patent: 3996006 (1976-12-01), Pagano
patent: 4018662 (1977-04-01), Ruhenstroth-Bauer et al.
patent: 4094647 (1978-06-01), Deutsch et al.
patent: 4108729 (1978-08-01), Mennen
patent: 4110079 (1978-08-01), Schaeffer
patent: 4168146 (1979-09-01), Grubb et al.
patent: 4189304 (1980-02-01), Adams, Jr. et al.
patent: 4223089 (1980-09-01), Rothe et al.
patent: 4246339 (1981-01-01), Cole et al.
patent: 4256693 (1981-03-01), Kondo et al.
patent: 4299916 (1981-11-01), Litman et al.
patent: 4313734 (1982-02-01), Leuvering
patent: 4333733 (1982-06-01), Sanford et al.
patent: 4365970 (1982-12-01), Lawrence et al.
patent: 4366241 (1982-12-01), Tom et al.
patent: 4376110 (1983-03-01), David et al.
patent: 4391904 (1983-07-01), Litman et al.
patent: 4425438 (1984-01-01), Bauman et al.
patent: 4427769 (1984-01-01), Adlercreutz et al.
patent: 4435504 (1984-03-01), Zuk et al.
patent: 4442204 (1984-04-01), Greenquist et al.
patent: 4444193 (1984-04-01), Fogt et al.
patent: 4446232 (1984-05-01), Liotta
patent: 4447526 (1984-05-01), Rupchock et al.
patent: 4447529 (1984-05-01), Greenquist et al.
patent: 4459358 (1984-07-01), Berke
patent: 4461829 (1984-07-01), Greenquist
patent: 4474878 (1984-10-01), Halbert et al.
patent: 4477575 (1984-10-01), Vogel et al.
patent: 4517288 (1985-05-01), Giegel et al.
patent: 4533629 (1985-08-01), Litman et al.
patent: 4582811 (1986-04-01), Pucci et al.
patent: 4594327 (1986-06-01), Zuk
patent: 4623461 (1986-11-01), Hossom et al.
patent: 4629690 (1986-12-01), Weng et al.
patent: 4642285 (1987-02-01), Halbert et al.
patent: 4668619 (1987-05-01), Greenquist et al.
patent: 4678757 (1987-07-01), Rapkin et al.
patent: 4683197 (1987-07-01), Gallati
patent: 4690907 (1987-09-01), Hibino et al.
patent: 4693834 (1987-09-01), Hossom
patent: 4703017 (1987-10-01), Campbell et al.
patent: 4717656 (1988-01-01), Swanljung
patent: 4738823 (1988-04-01), Engelmann
patent: 4740468 (1988-04-01), Weng et al.
patent: 4752562 (1988-06-01), Sheiman et al.
patent: 4761381 (1988-08-01), Blatt et al.
patent: 4775636 (1988-10-01), Moeremans et al.
patent: 4780280 (1988-10-01), Berger et al.
patent: 4786594 (1988-11-01), Khanna et al.
patent: 4789526 (1988-12-01), Matkovich
patent: 4789629 (1988-12-01), Baker et al.
patent: 4790979 (1988-12-01), Terminiello et al.
patent: 4797260 (1989-01-01), Parker
patent: 4803170 (1989-02-01), Stanton et al.
patent: 4806311 (1989-02-01), Greenquist
patent: 4806312 (1989-02-01), Greenquist
patent: 4810470 (1989-03-01), Burkhardt et al.
patent: 4814142 (1989-03-01), Gleisner
patent: 4816224 (1989-03-01), Vogel et al.
patent: 4818677 (1989-04-01), Hay-Kaufman et al.
patent: 4826759 (1989-05-01), Guire et al.
patent: 4837373 (1989-06-01), Gunkel et al.
patent: 4837395 (1989-06-01), Leeder et al.
patent: 4843000 (1989-06-01), Litman et al.
patent: 4853335 (1989-08-01), Olsen et al.
patent: 4855240 (1989-08-01), Rosenstein et al.
patent: 4857453 (1989-08-01), Ullman et al.
patent: 4859612 (1989-08-01), Cole et al.
patent: 4861711 (1989-08-01), Friesen et al.
patent: 4868108 (1989-09-01), Bahar et al.
patent: 4876067 (1989-10-01), Deneke et al.
patent: 4877586 (1989-10-01), Devaney, Jr. et al.
patent: 4879215 (1989-11-01), Weng et al.
patent: 4883764 (1989-11-01), Kloepfer
patent: 4900663 (1990-02-01), Wie et al.
patent: 4912034 (1990-03-01), Kalra et al.
patent: 4916056 (1990-04-01), Brown, III et al.
patent: 4916078 (1990-04-01), Klose et al.
patent: 4918025 (1990-04-01), Grenner
patent: 4920046 (1990-04-01), McFarland et al.
patent: 4938927 (1990-07-01), Kelton et al.
patent: 4939098 (1990-07-01), Suzuki et al.
patent: 4943522 (1990-07-01), Eisinger et al.
patent: 4952517 (1990-08-01), Bahar
patent: 4956275 (1990-09-01), Zuk et al.
patent: 4956302 (1990-09-01), Gordon et al.
patent: 4959307 (1990-09-01), Olson
patent: 4960691 (1990-10-01), Gordon et al.
patent: 4963325 (1990-10-01), Lennon et al.
patent: 4963468 (1990-10-01), Olson
patent: 4977078 (1990-12-01), Niimura et al.
patent: 4981786 (1991-01-01), Dafforn et al.
patent: 4999285 (1991-03-01), Stiso
patent: 4999287 (1991-03-01), Allen et al.
patent: 5006464 (1991-04-01), Chu et al.
patent: 5006474 (1991-04-01), Horstman et al.
patent: 5030555 (1991-07-01), Clemmons
patent: 5030558 (1991-07-01), Litman et al.
patent: 5039607 (1991-08-01), Skold et al.
patent: 5051237 (1991-09-01), Grenner et al.
patent: 5071746 (1991-12-01), Wilk et al.
patent: 5073484 (1991-12-01), Swanson et al.
patent: 5075078 (1991-12-01), Osikowicz et al.
patent: 5079142 (1992-01-01), Coleman et al.
patent: 5079174 (1992-01-01), Buck et al.
patent: 5085987 (1992-02-01), Olson
patent: 5085988 (1992-02-01), Olson
patent: 5096809 (1992-03-01), Chen et al.
patent: 5100619 (1992-03-01), Baker et al.
patent: 5104811 (1992-04-01), Berger et al.
patent: 5104812 (1992-04-01), Kurn et al.
patent: 5106582 (1992-04-01), Baker
patent: 5106758 (1992-04-01), Adler et al.
patent: 5110550 (1992-05-01), Schlipfenbacher et al.
patent: 5114673 (1992-05-01), Berger et al.
patent: 5114862 (1992-05-01), Brenneman
patent: 5120643 (1992-06-01), Ching et al.
patent: 5120662 (1992-06-01), Chan et al.
patent: 5132208 (1992-07-01), Freitag et al.
patent: 5135872 (1992-08-01), Pouletty et al.
patent: 5135873 (1992-08-01), Patel et al.
patent: 5137804 (1992-08-01), Greene et al.
patent: 5137808 (1992-08-01), Ullman et al.
patent: 5141850 (1992-08-01), Cole et al.
patent: 5156952 (1992-10-01), Litman et al.
patent: 5158869 (1992-10-01), Pouletty et al.
patent: 5160486 (1992-11-01), Schlipfenbacher et al.
patent: 5162237 (1992-11-01), Messenger et al.
patent: 5164294 (1992-11-01), Skold et al.
patent: 5177021 (1993-01-01), Kondo
patent: 5182191 (1993-01-01), Fan et al.
patent: 5185127 (1993-02-01), Vonk
patent: 5188939 (1993-02-01), Mangold et al.
patent: 5188966 (1993-02-01), Eikmeier et al.
patent: 5202267 (1993-04-01), Ditlow et al.
patent: 5202268 (1993-04-01), Kuhn et al.
patent: 5209904 (1993-05-01), Forney et al.
patent: 5223436 (1993-06-01), Freitag et al.
patent: 5234813 (1993-08-01), McGeehan et al.
patent: 5248619 (1993-09-01), Skold et al.
patent: 5256372 (1993-10-01), Brooks et al.
patent: 5258163 (1993-11-01), Krause et al.
patent: 5260193 (1993-11-01), Olson
patent: 5260222 (1993-11-01), Patel et al.
patent: 5264180 (1993-11-01), Allen et al.
patent: 5275785 (1994-01-01), May et al.
patent: 5278079 (1994-01-01), Gubinski et al.
patent: 5308580 (1994-05-01), Clark
patent: 5314804 (1994-05-01), Boguslaski et al.
patent: 5415994 (1995-05-01), Imrich et al.

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