2-substituted-6-carbadethiapen-2-em-3-carboxylic acids

Details 2-substituted-6-carbadethiapen-2-em-3-carboxylic acids 2-substituted-6-carbadethiapen-2-em-3-carboxylic acids

1987-02-26

1991-02-12

Rizzo, Nicholas S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Unsubstituted hydrocarbyl chain between the ring and the -c-...

C07D48704, A61K 3140

Patent

active

049925423

ABSTRACT:
Disclosed are 2- and 6-substituted-1-carbadethiapen-2-em-3-carboxylic acids having the structure: ##STR1## wherein R.sup.6, R.sup.7 and R.sup.8 are inter alia, independently selected from the group consisting of hydrogen, alkyl, alkenyl, aryl and aralkyl. Such compounds as well as their pharmaceutically acceptable salt, ester and amide derivatives are useful as antibiotics. Also disclosed are processes for the preparation of such compounds, pharmaceutical compositions comprising such compounds and methods of treatment comprising administering such compounds and compositions when an antibiotic effect is indicated.

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