Process for producing optically active 4-hydroxy-2-ketoglutaric

Details Process for producing optically active 4-hydroxy-2-ketoglutaric Process for producing optically active 4-hydroxy-2-ketoglutaric

1995-02-28

1997-03-04

Marx, Irene

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing oxygen-containing organic compound

435822, 435874, 435877, C12P 750

Patent

active

056078480

ABSTRACT:
The present invention provides a process for producing an optically active 4-hydroxy-2-ketoglutaric acid, by mixing glyoxylic acid, pyruvic acid and a microorganism to form the optically active 4-hydroxy-2-ketoglutaric acid in an aqueous medium.

REFERENCES:
patent: 5374542 (1994-12-01), Katsumata et al.
Maruyama K, J. Biochem 108:327-333 (1990).
ATCC Catalogue of Bacteria and Bacteriophages pp. v and 78 (1992).
"Metabolism of .gamma.-Hydroxyglutamic Acid", A. Goldstone et al., The Journal of Biological Chemistry, 237(11):3476-3485 (1962).
"Enzymatic Steps in the Conversion of .gamma.-Hydroxyglutamate to Glyoxylate and Alanine", U. Maitra et al., The Journal of Biological Chemistry, 238 (11):3660-3669 (1963).
"DL-2-Keto-4-hydroxyglutarate", E. E. Dekker et al., Methods in Enzymology, vol. XLI, pp. 115-118 (1975).

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