Phenyl substituted heterocyclic compounds

Details Phenyl substituted heterocyclic compounds Phenyl substituted heterocyclic compounds

1993-07-16

1995-08-22

Rotman, Alan L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546125, 546124, C07D41304, C07D40104, A61K 3144

Patent

active

054440700

ABSTRACT:
The present invention discloses compounds of the formula ##STR1## any mixture thereof, or a pharmaceutically acceptable salt thereof; wherein R, R.sub.3, and R.sup.4 each have the meanings set forth in the specification.
The compounds possess valuable pharmaceutical properties as dopamine reuptake inhibitors.

REFERENCES:
R. L. Clarke et al., J. Med. Chem. 16(11), 1261-1267 (1973).
F. Ivy Carroll et al., J. Med. Chem. 34, 883-883 (1991).
Meltzer et al., J. Med. Chem. 36(7), 855-862 (1993).
F. Ivy Carroll et al., J. Chem. Soc., Chem. Commun., 44-46 (1993).
F. Ivy Carroll et al., Abstracts of 205th ACS meeting, Denver, Colo., Mar. 28-Apr. 2, 1993, item 84 (Feb. 26, 1993).
van Haaren, F., Elsevier Science Publishers, Chapter 2 by Porsolt et al. (1993), entitled "Methods in Behavioural Pharmacology".
J. F. Teste et al., Fundam. Clin. Pharmacol. 7, 219-226 (1993).

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