Method of culturing lymphocytes and method of treatment using su

Details Method of culturing lymphocytes and method of treatment using su Method of culturing lymphocytes and method of treatment using su

1988-03-21

1995-08-22

Elliott, George C.

Chemistry: molecular biology and microbiology

Spore forming or isolating process

435 2, 43524025, C12N 502, C12N 508

Patent

active

054439833

ABSTRACT:
In accordance with the present invention, a method of culturing lymphocytes is disclosed in which the lymphocytes are cultured in the presence of interleukin-2 (IL-2) and an antibody to a lymphocyte surface receptor, preferably an antibody to a lymphocyte T3 surface receptor. Preferably, the antibody is monoclonal. Cells cultured with anti-CD3 maintain their LAK activity as they increase in number. The cells can also be cultured in the presence of an additional lymphokine to obtain additional LAK activity.
Methods of medical treatment are also disclosed in which cells cultured in accordance with the culturing methods of the present invention are introduced into the individual to be treated.

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