Piperidine derivatives, their preparation and their application

Details Piperidine derivatives, their preparation and their application Piperidine derivatives, their preparation and their application

1993-09-27

1995-05-23

Chang, Celia

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546199, A61K 31445, C07D40114

Patent

active

054182417

ABSTRACT:
The invention provides a compound which is a piperidine derivative of formula (I) ##STR1## in which R.sub.1 is hydrogen or straight or branched (C.sub.1 -C.sub.6) alkyl, R.sub.2 is hydrogen or straight or branched (C.sub.1 -C.sub.8) alkyl, Z and Z.sub.1 which may be the same or different, each is hydrogen, chlorine, hydroxyl, amino, nitro, hydroxymethyl, (C.sub.1 -C.sub.2) alkyl, (C.sub.1 -C.sub.8) alkoxy straight or branched (C.sub.1 -C.sub.5) alkoxycarbonyl or aryl (C.sub.1 -C.sub.2) alkoxy, Z is in position 4, 6 or 7 and Z and Z.sub.1 cannot both be hydrogen, or its addition salt with a pharmaceutically acceptable acid and its therapeutic application.

REFERENCES:
patent: 5008390 (1991-04-01), Bender
patent: 5192775 (1993-03-01), Malen
patent: 5280030 (1994-01-01), Jegham
C. A. Lipinski et al., "Bioisoteric prototype design . . . ", vol. 29, No. 11, Nov. 1986, Journal of Medicinal Chemistry, Washington, USA.
W. Schunack, vol. 306, No. 12, Dec. 1973, Archiv der Pharmazie, Weinheim, Germany.
Hayashi et al "5HT.sub.3 Receptor Antagonists" J. Med. Chem. 35 4893-4902 (1992).
Glennon "Central Serotonin Receptors as Target for Drug Research" J. Med. Chem. 30 1-12 (1967).

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