Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1998-06-01
1999-11-02
Higel, Floyd D.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514399, 514400, 5483151, 5483171, 5483225, 5483335, 5483355, 5483431, 5483435, 5483461, A61K 31415, C07D23302, C07D23338, C07D23340
Patent
active
059771550
ABSTRACT:
Products of formula (1), wherein R.sub.1 is particularly ##STR1## alkyl, alkylthio or alkoxy; R.sub.2 is particularly halogen, --S--R, --O--R or --C(OH)(R)--COOH, where R is alkyl or alkenyl; R.sub.3 is particularly carboxy, acyl, halogen, alkyl, alkenyl or alkylthio; and R.sub.4 is particularly --(CH.sub.2).sub.m1 --COOR.sub.4, --(CH.sub.2).sub.m1 --CONHR.sub.14, --(CH.sub.2).sub.m1 --CN, --SO.sub.2 --NH--SO.sub.2 --R.sub.14, 13 NH--SO.sub.2 --R.sub.14, --PO.sub.3 R.sub.14, or --NH--SO.sub.2 --CF.sub.3, where m1 is 0-4 and R.sub.14 is hydrogen, alkyl or alkenyl; are useful for preparing pharmaceutical compositions for treating disorders resulting from abnormal stimulation of angiotensin II receptors AT.sub.1 and AT.sub.2.
REFERENCES:
patent: 5527919 (1996-06-01), Bhatnagar et al.
patent: 5811445 (1998-09-01), Corbier et al.
Pharmacology vol. 120, p. 21 Biorganic & Medical, 1994.
Chemistry Letters, vol. 4, No. 1, pp. 69-74, 1994.
Corbier Alain
Deprez Pierre
Fortin Michel
Guillaume Jacques
Heckmann Bertrand
Higel Floyd D.
Hoechst Marion Roussel
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