Substituted 7-oxomitosanes

Details Substituted 7-oxomitosanes Substituted 7-oxomitosanes

1988-11-07

1990-05-22

Rizzo, Nicholas S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D48714, A61K 3140

Patent

active

049279432

ABSTRACT:
The present invention provides novel mitomycin analogs containing a disulfide group and processes for the preparation thereof. These compounds are mitomycin A analogs in which the 7-alkoxy group bears an organic substituent incorporating a disulfide group. Mitomycin A is an antibiotic of established utility, and the 7-O-substituted mitosane analogs thereof have similar utility.

REFERENCES:
patent: 4069324 (1978-01-01), Wiederkehr et al.
patent: 4803212 (1089-02-01), Vyas et al.
Shirhata et al., J. Amer. Chem. Soc., 105, 7199-7200 (1983).
Urakawa et al., J. Antibiotics, 23, 804-809 (1980).
Matsui et al., J. Antibiotics, XXI, 189-198 (1968).
Farmdoc No. 56627, E. H. White et al., Org. Syn., 48, 102-105 (1968).
Mangia, Tetrahedron Letters, No. 52, pp. 5219-5220 (1978), White, Tetrahedron Letters, No. 21.

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