Cilansetron pharmaceutical preparation stabilized against racemi

Details Cilansetron pharmaceutical preparation stabilized against racemi Cilansetron pharmaceutical preparation stabilized against racemi

1998-07-31

1999-11-02

Krass, Frederick

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514397, 514962, 514960, 514970, 514973, 424451, 424452, 424464, 424465, 424489, A01N 4342, A61K 3144

Patent

active

059771275

ABSTRACT:
Solid and liquid pharmaceutical preparations containing cilansetron or its acid addition salts as active substance which include an amount sufficient to stabilize cilansetron against racemization, of a physiologically compatible water-soluble acid additive selected from monobasic or multibasic organic acids having 2 to 12 carbon atoms with a first p.sub.s value between 1.1 and 4.8, acid salts of the aforementioned multibasic organic acids, and acid salts of multibasic mineral acids having a first available pK.sub.s value between 1.5 and 7.5, as well as the use of such acid additives for stabilizing cilansetron against racemization in pharmaceutical preparations.

REFERENCES:
patent: 4939136 (1990-07-01), Haeck et al.
patent: 5438068 (1995-08-01), Eeckhout et al.
patent: 5663343 (1997-09-01), van der Meij et al.

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