Substituted guanidine derivatives, process for production thereo

Details Substituted guanidine derivatives, process for production thereo Substituted guanidine derivatives, process for production thereo

1998-05-08

1999-11-02

Raymond, Richard L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

540522, 540586, A61K 3155, C07D48700, C07D22314

Patent

active

059771003

ABSTRACT:
A substituted guanidine derivative represented by the general formula: ##STR1## wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are independently a hydrogen atom, an unsubstituted alkyl group, a substituted alkyl group, a halogen atom or the like; Y.sub.1, Y.sub.2, Y.sub.3, Y.sub.4, Y.sub.5, Y.sub.6 and Y.sub.7, which may be the same or different, are independently a single bond, --CH.sub.2 --, --O--, --CO-- or the like, adjacent members of a group consisting of Y.sub.1 through Y.sub.7 being able to be taken together to represent --CH.dbd.CH--, and at least two of Y.sub.1 through Y.sub.7 being independently a group other than a single bond; Z may be absent, or one or more Zs may be present and are, the same or different, independently a substituent for a hydrogen atom bonded to any of the carbon atoms constituting the ring formed by Y.sub.1 through Y.sub.7, for example, an unsubstituted alkyl group or a substituted alkyl group, or a pharmaceutically acceptable acid addition salt thereof, is useful as a therapeutic or prophylactic agent for diseases caused by the acceleration of the sodium/proton (Na.sup.+ /H.sup.+) exchange transport system, for example, hyperpiesia, arrhythmia, angina pectoris, hypercardia, diabetes, organopathies due to ischemia or ischemia re-perfusion, troubles due to cerebral ischemia, diseases caused by cell over-proliferations, and diseases caused by trouble with endothelial cells.

REFERENCES:
patent: 4567177 (1986-01-01), Bigg et al.
patent: 5814654 (1998-09-01), Kitano et al.
Journal of the American Chemical Society, vol. 80, No. 20, Oct. 20, 1958, pp. 5574-5575.
Khim. Geterotsikl. Soedin., No. 6, 1979, pp. 839-841.
Khim. Geterotsikl. Soedin., No. 7, 1981, pp. 983-986.

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