Ester substituted aminoalkanoylureido amino and imino acid and e

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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544282, 514333, 514339, 514341, 514343, 514397, 514414, 546 14, 546147, 546256, 546268, 546273, 546276, 546278, 546281, 548188, 548336, 548356, 548406, 548409, 548454, 548452, 548455, 548456, 548465, 548467, 548468, 548517, 548527, 548533, 548953, 560 16, C07D20704, A61K 3140, A61K 3134, A61K 3138

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active

046380108

ABSTRACT:
Compounds of the formula ##STR1## are disclosed. These compounds are useful as hypotensive agents due to their angiotensin converting enzyme inhibition activity and depending upon the definition of X may also be useful as analgesics due to their enkephalinase inhibition activity.

REFERENCES:
patent: 4329473 (1982-05-01), Almquist et al.
patent: 4402969 (1983-09-01), Greenlee et al.
patent: 4470793 (1984-09-01), Natarajan et al.
Meyer et al., "Novel Synthesis of . . . ", J. Med. Chem., 1981, vol. 24, pp. 964-969.
Almquist et al., "Derivatives of Potent Angiotensin Converting Enzyme Inhibitor . . . ", J. Med. Chem., 1982, vol. 25, 1292-1299.

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