Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1985-02-28
1987-01-20
Brust, Joseph Paul
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
544282, 514333, 514339, 514341, 514343, 514397, 514414, 546 14, 546147, 546256, 546268, 546273, 546276, 546278, 546281, 548188, 548336, 548356, 548406, 548409, 548454, 548452, 548455, 548456, 548465, 548467, 548468, 548517, 548527, 548533, 548953, 560 16, C07D20704, A61K 3140, A61K 3134, A61K 3138
Patent
active
046380108
ABSTRACT:
Compounds of the formula ##STR1## are disclosed. These compounds are useful as hypotensive agents due to their angiotensin converting enzyme inhibition activity and depending upon the definition of X may also be useful as analgesics due to their enkephalinase inhibition activity.
REFERENCES:
patent: 4329473 (1982-05-01), Almquist et al.
patent: 4402969 (1983-09-01), Greenlee et al.
patent: 4470793 (1984-09-01), Natarajan et al.
Meyer et al., "Novel Synthesis of . . . ", J. Med. Chem., 1981, vol. 24, pp. 964-969.
Almquist et al., "Derivatives of Potent Angiotensin Converting Enzyme Inhibitor . . . ", J. Med. Chem., 1982, vol. 25, 1292-1299.
Gordon Eric M.
Weller, III Harold N.
Brust Joseph Paul
Davis Stephen B.
E. R. Squibb & Sons Inc.
Levinson Lawrence S.
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