Apparatus and method for therapeutic immunodepletion

Details Apparatus and method for therapeutic immunodepletion Apparatus and method for therapeutic immunodepletion

1984-06-01

1987-01-20

Spear, Frank

Liquid purification or separation

Processes

Liquid/liquid solvent or colloidal extraction or diffusing...

210264, 210927, B01D 1300

Patent

active

046378804

ABSTRACT:
A therapeutic apparatus for the removal of a harmful agent from blood is provided in the form of an array of hollow fiber bundles connected in parallel, wherein the interior surfaces of the individual hollow fibers are coated with a covalently bound proteinaceous or other immunoadsorbent selected for specific removal of the harmful agent. In the disclosed method the apparatus is optionally connected as an extracorporeal shunt between the artery and vein of a patient to be treated and the blood is alternately routed through one fiber bundle while the remaining fiber bundles undergo regeneration. Specific embodiments include the removal of rheumatoid factor by covalently bound immunoglobulin G and the removal of digoxin by covalently bound anti-digoxin.

REFERENCES:
patent: 3638794 (1972-02-01), Holzer
patent: 4061141 (1977-12-01), Hyden et al.
patent: 4118314 (1978-10-01), Yoshida
patent: 4127481 (1978-11-01), Malchesky et al.
patent: 4192748 (1980-03-01), Hyden
patent: 4201673 (1980-05-01), Kanno et al.
patent: 4228013 (1980-10-01), Degenkolb et al.
patent: 4356267 (1982-10-01), Callegaro et al.
patent: 4375414 (1983-03-01), Strahilevitz
Terman et al., "Removal of Circulating Antigen and Immune Complexes with Immunoreactive Collodion Membranes", from FEBS Letters, vol. 68, No. 1, pp. 89-94, 9-1976, North-Holland Publishing Co.--Amsterdam.

Affiliated with

Also associated with

Rating

Apparatus and method for therapeutic immunodepletion does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Apparatus and method for therapeutic immunodepletion, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Apparatus and method for therapeutic immunodepletion will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2133943