Nucleic acid sequences controlling lung cell-specific gene expre

Details Nucleic acid sequences controlling lung cell-specific gene expre Nucleic acid sequences controlling lung cell-specific gene expre

1995-05-17

1999-11-02

Brusca, John S.

Chemistry: molecular biology and microbiology

Vector, per se

536 241, 4284022, C12N 1563, C12N 1511, B32B 516

Patent

active

059768738

ABSTRACT:
An oligonucleotide which includes at least one nucleic acid sequence which binds to at least one nuclear protein found in lung cells, such as TTF-1 protein. The oligonucleotide may be contained in a vector. The at least one nuclear protein provides for lung cell-specific expression of the vector upon binding of the at least one nucleic acid sequence to the at least one nuclear protein. Such vector may also include genes encoding therapeutic agents, and may be employed for delivering genes encoding therapeutic agents to lung cells.

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