Process for the preparation of optically pure 1,2,3,4-tetrahydro

Details Process for the preparation of optically pure 1,2,3,4-tetrahydro Process for the preparation of optically pure 1,2,3,4-tetrahydro

1996-01-03

1997-05-06

Davis, Zinna Northington

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D21726

Patent

active

056272820

ABSTRACT:
This invention relates to the preparation of optically pure tetrahydro-3-isoquinolinecarboxylic acid derivative of formula (III) which comprises the reaction of optically pure phenylalanine derivative of formula (I) with a formaldehyde precursor, such as formaline, trioxane, dialkoxymethane, or paraformaldehyde, for about 10 hours to 60 hours at about 40 .degree. C. to about 60 .degree. C. in concentrated hydrochloric acid to give the compound of formula (II), followed by neutralization in hot water at about 70 .degree. C. to about 100 .degree. C. with a base, such as ammonium hydroxide, potassium carbonate, sodium carbonate, sodium hydroxide or potassium hydroxide, according to the following reaction scheme. ##STR1##

REFERENCES:
patent: 4912221 (1990-03-01), O'Reilly et al.
Miyake et al. "Takeda Research Laboratory", 43 (314), 53-76 (1984).
Kammermeier et al. "Synthesis", Nov., 1992 1157-1160.

Affiliated with

Also associated with

Rating

Process for the preparation of optically pure 1,2,3,4-tetrahydro does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for the preparation of optically pure 1,2,3,4-tetrahydro, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for the preparation of optically pure 1,2,3,4-tetrahydro will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2133718