Method for analyzing oligonucleotide analogs

Details Method for analyzing oligonucleotide analogs Method for analyzing oligonucleotide analogs

1994-01-07

1997-05-06

Jones, W. Gary

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

204455, 435 6, 435 912, 435 911, 514 44, C07H 2100, G01N 2726, A61K 4800, C12P 1934

Patent

active

056272774

ABSTRACT:
Disclosed is a substrate useful for separating unmodified and modified mononucleotides and oligonucleotides. The substrate includes at least 12% (weight:volume) polymer in at least 5M urea and at least 32% (volume:volume) organic solvent, the organic solvent being a chemically stable liquid at room temperature and having a dielectric constant of at least 20. Also provided is a method of separating unmodified and modified mononucleotides and/or oligonucleotides utilizing this substrate.

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