Relaxation of smooth vascular muscle

Details Relaxation of smooth vascular muscle Relaxation of smooth vascular muscle

1987-12-17

1990-05-22

Hearn, Brian E.

Drug, bio-affecting and body treating compositions

Enzyme or coenzyme containing

Hydrolases

A61K 3748

Patent

active

049276298

ABSTRACT:
Certain substances are provided which have the ability to relax smooth vascular muscle, having an endothelial lining, when administered in vitro or by intravenous injection. Examples of useful substances which are pharmaceutically-acceptable include phospholipase A.sub.2 (PLA.sub.2) and certain lysolecithins. The concentration required is at least about 3 units of PLA.sub.2 and at least about 10.sup.-5 Molar lysolecithin. The lysolecithins are dissolved in a suitable solvent, such as dimethyl sulfoxide, for injection. Alternatively, phospholipase A.sub.2 is administered directly. The resulting solutions should have a pharmacologically-effective amount of the substance dissolved therein. Importantly, the body does not develop a tolerance to the lysolecithin.

REFERENCES:
patent: 4699919 (1987-10-01), Follet et al.
patent: 4788304 (1988-11-01), Marshall et al.
patent: 4826821 (1989-05-01), Clements
Chemical Abstracts, 101:83569v; 86:37623g; 76:121521y; 108:129304e; 108:202449n; 110:5309g; 109:71073f.
Rogausch, H., Research Experimental Medicine, (173) (1) (1978), pp. 9-16, abstract only.

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