Arylethenylene compounds which are useful as tyrosine kinase inh

Details Arylethenylene compounds which are useful as tyrosine kinase inh Arylethenylene compounds which are useful as tyrosine kinase inh

1995-05-31

1997-05-06

Davis, Zinna Northington

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

514521, 514523, 514525, 558401, A61K 31275, C07C25530

Patent

active

056272073

ABSTRACT:
The present invention provides compounds of the formula ##STR1## wherein Y is a naphthyl, tetrahydronaphthyl, pyridyl, quinolyl, isoquinolyl or indolyl ring system, R is a moiety which is an acrylic acid, a CN-substituted acrylic acid, acrylamide, acrylonitrile or thioacrylamide, or a group of formulae (e) to (j): ##STR2## wherein R.sub.3 is OH or NH.sub.2, R.sub.1 is H, alkyl or alkanoyl, R.sub.2 is H, halogen, CN or alkyl; and n is 0, 1, 2 or 3; and the pharmaceutically acceptable salts thereof are useful as tyrosine kinase inhibitors.

REFERENCES:
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patent: 5130472 (1992-07-01), Buzzetti et al.
patent: 5374652 (1994-12-01), Buzzetti et al.
patent: 5397787 (1995-03-01), Buzzetti et al.
patent: 5409949 (1995-04-01), Buzzetti et al.
Nagai, Nagoya Kogyo Daigaku Gakuho, vol. 22, 1970 pp. 143-149.

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