Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1995-08-03
1997-05-06
Chan, Nicky
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514469, 549406, 549408, 549410, 549462, 549469, 549470, A61K 3135, A61K 3134, C07D31172, C07D30780
Patent
active
056272057
ABSTRACT:
New substituted phenoxyisobutyric acids and esters that can be used as medicaments and correspond to the formula: ##STR1## wherein X, A, R, R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7 and Z are as defined in the description.
Those compounds and their physiologically tolerable salts can be used therapeutically.
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Serum Antioxidants and Myocardial Infarction by Street, et al., American Heart Association, Inc., pp. 1154-1161 (1994).
Antioxidant vitamins and coronary heart disease risk by Clifton, Division of Human Nutrition, Commonwealth Scientific and Industrial Research Organisation, Adelaide, Australia, Current Opinion in Lipidology 1995, 6:20-24.
Effect of Alpha-tocopherol on Restenosis after Angioplasty in a Model of Experimental Atherosclerosis by Lafont, et al., J. Clin. Invest., vol. 95, pp. 1018-1025 (Mar. 1995).
Immunization of low density lipoprotein (LDL) receptor-deficient rabbits with homologous malondialdehyde-modified LDL reduces atherogenesis by Palinski, et al., Proc. Natl. Acad. Sci. USA, vol. 92, pp. 821-825 (Jan. 1995) Medical Sciences.
Breugnot Christine
Guillonneau Claude
Lenaers Albert
Regnier Gilbert
Vilaine Jean-Paul
Adir et Compagnie
Chan Nicky
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