Anti-viral guanidino-substituted compounds

Details Anti-viral guanidino-substituted compounds Anti-viral guanidino-substituted compounds

1994-10-14

1997-05-06

Clardy, S. Mark

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514432, 514459, 514460, 546247, 546243, 549 13, 549 28, 549417, 549419, 564236, A61K 3135, A61K 3138, A61K 31445, A61K 3117

Patent

active

056271948

ABSTRACT:
Novel guanidino-substituted compounds are described having the following general formula (I): ##STR1## in which X may be carbon, oxygen, nitrogen or sulfur; R.sub.1 may be H, OH, linear or branched lower alkyl, lower alkoxy, lower (alkyl-substituted alkoxy), lower alkyl-amine, lower alkyl-thio, hydroxy substituted lower alkoxy, lower alkoxy-alkoxy substituted lower alkoxy, hydroxy substituted lower alkyl-amine, alkoxy substituted lower alkyl-amine and terminally guanidino-substituted linear of branched lower alkyl, lower alkoxy, lower (alkyl-substituted alkoxy), lower alkyl-amine or lower alkyl-thio; and R.sub.2 and R.sub.3 are independently one of linear or branched lower alkyl, alkoxy, alkyl-substituted alkoxy and alkylamine.
These compounds have been found to inhibit effectively herpesvirus replication. Particularly preferred compounds in accordance with formula (I) for this purpose are guanidino-substituted sugar derivatives.

REFERENCES:
patent: 2557560 (1951-06-01), Peck
patent: 3468898 (1969-09-01), Cutler et al.
Hine et al., "Octakis-O-(3-aminopropyl) sucrose as a Bifunctional Catalyst for the Dedeuteration of Isobutyraldehyde-2-d.sup.1 ", J. Org. Chem., vol. 39, No. 22 (1974), pp. 3231-3236.
Nicolalou et al., "Design and synthesis of a peptidomimetic employing .beta.-D-glucose for scaffolding", Peptides: Chem Structure Biol., 11th An Pepetide Symp. (1990), pp. 881-884.
Shankar et al., "A novel application of benzotriazole methodology: reactions of polyhydroxylated bis-(benzotriazoyl) piperidines with mono and bidentate nucleophiles", Tetrahedron Letters, vol. 34, No. 45, (1993), pp. 7171-7174.

Affiliated with

Also associated with

Rating

Anti-viral guanidino-substituted compounds does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Anti-viral guanidino-substituted compounds, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Anti-viral guanidino-substituted compounds will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2132908