Acyclovir derivatives as antiviral agents

Details Acyclovir derivatives as antiviral agents Acyclovir derivatives as antiviral agents

1995-06-05

1997-05-06

Wilson, James O.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514261, 514262, 514885, 514894, 544264, 544265, A61K 3152

Patent

active

056271859

ABSTRACT:
Derivatives of Acyclovir are provided having patent antiviral inhibitory activity. Phosphotriester derviatives are preferred which have the structure: ##STR1## where R is alkyl, especially CH.sub.3 or (CH.sub.3).sub.3 C.

REFERENCES:
patent: 4294831 (1981-10-01), Schaffer
patent: 4355032 (1982-10-01), Verheyden et al.
patent: 5284837 (1994-02-01), Lindborg et al.
patent: 5494912 (1996-02-01), Halazy et al.
Hao et al., "2', 3'-Dideoxyuridine Triphosphate: A Potent Inhibitor of HIV Reverse Transcriptase," Proceedings of AACR, vol. 29, p. 348 (1988).
Hao et al., Molecular Pharmacology, vol. 37, pp. 157-163 (1989).
Rosenberg et al., Collection Czech Chem. Commun., vol. 52 pp. 2792-2800. (1987).
Matthes et al., Biochem and Biophysical Research Commun., vol. 148, No. 1, pp. 78-85, (1987).

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