Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1995-12-05
1997-05-06
Knode, Marian C.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
435 72, 435 723, 435 4052, 536 2431, C12Q 168, G01N 33574, G01N 3353, C07H 2104
Patent
active
056270348
ABSTRACT:
A method of determining the proliferative status of a carcinoma is disclosed. One obtains a patient sample and then quantitatively analyzes the sample for NGAL gene expression product. The amount of NGAL expression product is compared with a standard curve to determine the S-phase value. The sample can be breast tissue or breast fluid aspirate. Alternatively, blood can by analyzed for this marker to diagnose metastasis.
REFERENCES:
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Kjeldsen, L. et al. European Journal of Clinical Investigation. 25(Suppl. 2):A33 1995.
S. Bartsch, et al., Cloning And Expression Of Human Neutrophil Lipocalin cDNA Derived From Bone Marrow And Ovarian Cancer Cells, 357 FEBS Letters 255-259 (1995).
J. Bundgaard, et al., Molecular Cloning And Expression Of A cDNA Encoding NGAL: A Lipocalin Expressed In Human Neutrophils, 202 Biochem. & Biophy. Res. Comm. 1468-1475 (1994).
L. Kjeldsen, et al., Isolation And Primary Structure Of NGAL, A Novel Protein Associated With Human Neutrophil Galatinase, 268 J. Bio. Chem. 10425-10432 (1993).
S. Stoesz, et al., Isolation Of A Lipocalin Uniquely Overexpressed In Neu-Initiated Rat Mammary, AACR Abstract (1994).
S. Stoesz, et al., Cloning Of Genes Overexpressed In Neu-Initiated Rat Mammary Tumors, AACR Abstract (1992).
S. Xu, et al., The Development Of An Assay For Human Neutrophil Lipocalin (HNL)-To Be Used As A Specific Marker Of Neutrophil Activity In Vivo And Vitro, 171 J. Immu. 245-252 (1994).
N. L. Petrakis, Nipple Aspirate Fluid In Epidemiologic Studies Of Breast Disease, 15 Epid. Rev. 188-195 (1993).
F. Hutchinson, et al., Simple And Complex Cell Cycles, 5 Animal Review 341-95 (1989).
Gould Michael N.
Stoesz Steven P.
Knode Marian C.
Lucas John
Wisconsin Alumni Research Foundation
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