Adjuvant composition containing synthetic hydrophobic lipopolysa

Details Adjuvant composition containing synthetic hydrophobic lipopolysa Adjuvant composition containing synthetic hydrophobic lipopolysa

1996-11-15

1999-11-02

Minnifield, Nita

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

4242781, 4242831, 424812, 424827, 42419711, 42419611, 4241931, 4241941, 514937, 514 54, A61K 39106, A61K 9127, A61K 39335, A61K 31715

Patent

active

059765380

ABSTRACT:
According to the present invention the adjuvants comprise an emulsion containing at least one synthetic hydrophobic lipopolysaccharide, which can either or not be provided with anionic groups, while maintaining the overall hydrophobicity, an interface-forming constituent (such as an oil) and optionally an aqueous solute. In particular the adjuvant and vaccines prepared with it contain a lipopolysaccharide which had an HLB value of less then 9, more favorably less than 4.

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