Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Implant or insert
Patent
1995-01-27
1997-05-06
Dodson, Shelley A.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Implant or insert
128898, 424489, 525 541, 525 542, 525408, 525413, 525415, 5147721, 5147723, 514773, 514777, 528354, 528361, A61K 958, C08G 6308
Patent
active
056268637
ABSTRACT:
Hydrogels of polymerized and crosslinked macromers comprising hydrophilic oligomers having biodegradable monomeric or oligomeric extensions, which biodegradable extensions are terminated on free ends with end cap monomers or oligomers capable of polymerization and cross linking are described. The hydrophilic core itself may be degradable, thus combining the core and extension functions. Macromers are polymerized using free radical initiators under the influence of long wavelength ultraviolet light, visible light excitation or thermal energy. Biodegradation occurs at the linkages within the extension oligomers and results in fragments which are non-toxic and easily removed from the body. Preferred applications for the hydrogels include prevention of adhesion formation after surgical procedures, controlled release of drugs and other bioactive species, temporary protection or separation of tissue surfaces, adhering of sealing tissues together, and preventing the attachment of cells to tissue surfaces.
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Desai Neil P.
Hill Jennifer L.
Hubbell Jeffrey A.
Pathak Chandrashekhar P.
Sawhney Amarpreet S.
Board of Regents , The University of Texas System
Dodson Shelley A.
Pabst Patrea L.
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