Method and composition for treatment of diabetes

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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514866, 4241951, A61K 3135, A61K 3578

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active

058860290

ABSTRACT:
A medicinal composition is provided for treatment of diabetes in a human subject. The medicinal composition of the invention induces a significant reduction in serum glucose due to the regeneration of pancreatic islet cells. A medicinal composition according to the invention necessarily includes a pharmacologically significant quantity of (-)epicatechin augmented with a comparable amount of gymnemic acid. For best results smaller quantities of cinnamomum tamala, syzygium cumini, trigonella foenum graceum, azardichta indica, ficus racemosa, and tinospora cordifolia are also included in the composition. One to two grams of the medicinal composition of the invention are administered to a diabetic human subject three times a day before meals. The unique combination of components in the medicinal composition leads to a regeneration of the pancreas cells which then start producing insulin on their own. Since the composition restores normal pancreatic function, treatment can be discontinued after between about four and twelve months.

REFERENCES:
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patent: 5730988 (1998-03-01), Womack
Seema et al., Chemical Abstract 125:218687 (1996).
Cha Hopadhyay, Chemical Abstracts 1996:301053.
Basnet et al., Chemical Abstracts 124:193946 (1995).
Functional Beta Cell Regeneration in the Islets of Pancreas in Alloxan Induced Diabetic Rats by (-)-Epicatechin by B.K. Chakravarthy, Saroj Gupte, and K. D. Gode Life Sciences, vol. 31, pp. 2693-2697 (1982).
Studies on Protein-Bound Polysaccharide Components & Glycosaminoglycans in Experimental Diabetes--Effect on Gymnema Sylvestre R.Br. Asha N. Baimi et al Indian Journal of Experimental Biology, vol. 19, Aug. 1981, pp. 715-721.
Effect of Trigonella Foenum Graecum (Fenugreek) on Blood Glucose in Norman and Diabetic Rats P. Khosla et al Indian Journal of Physiol Pharmacol, 1995: 39(2); 173-174.

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