N-containing condensed heterocyclic compounds, their production,

Details N-containing condensed heterocyclic compounds, their production, N-containing condensed heterocyclic compounds, their production,

1997-05-07

1999-03-23

Raymond, Richard L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514211, 514213, 514221, A61K 3133, A61K 3155

Patent

active

058859799

ABSTRACT:
N-containing, condensed heterocyclic compounds and salts thereof are disclosed which are useful for inhibiting squalene synthetase and fungal growth, and which are useful for treating or preventing hyperlipidemia. Also disclosed is a method for producing these compounds.

REFERENCES:
Feszt et al., "Influence of Some Benzodiazepines on Serum Lipids Levels in Hyperlipidaemic Rabbits" Agressologie, vol. 18, No. 5, (1977) pp. 265-267.
Horak et al., "Effects of Benzodizepine Derivatives on Triton WR-1339-Induced Hyperlipidemia in Rats", Atherosclerosis, vol. 24, (1976) pp. 81-97.
Journal of Medicinal Chemistry, vol. 31 (No. 10) Oct. 1988 pp. 1869-1871; S. A. Billier et al. Isoprenoid (Phosphinylmethyl) phosphonates as Inhibitors of Squalene Synthetase.
Chemical & Pharm. Bulletin, vol. 34 (No. 1) 1986 pp. 140-149; Y. Masuoka et al. "Synthesis of Medium=sized Heterocycles using an Intramolecular Michael-Reaction".
Shionogi & Co., Ltd., GBA--2 075 012; Nov. 11, 1981, Abstract.
Derwent Publications Ltd. No. 82-27355E/14, "Pharmaceutically active 4,1-benzoxazepine-3 acetic acid derivatives useful as minor-tranquilizers", 1982.
Takeda Chem. Ind., Chemical Abstracts, vol. 97, entry 127667 (1982).
Masuoka et al., Chemical Abstracts, vol. 106, entry 102252 (1986).

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