Methods of expressing angiostatic protein

Details Methods of expressing angiostatic protein Methods of expressing angiostatic protein

1995-04-26

1999-03-23

Ziska, Suzanne E.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

435 696, 4351723, 530300, 530350, 536 231, C12N 1500, C12P 2106, C07K 1400, C07H 2104

Patent

active

058857958

ABSTRACT:
The present invention comprises an endothelial inhibitor and method of use therefor. The endothelial inhibitor is a protein isolated from the blood or urine that is eluted as a single peak from C4-reverse phase high performance liquid chromatography. The endothelial inhibitor is a molecule comprising a protein having a molecular weight of between approximately 38 kilodaltons and 45 kilodaltons as determined by reducing polyacrylamide gel electrophoresis and having an amino acid sequence substantially similar to that of a murine plasminogen fragment beginning at amino acid number 98 of a murine plasminogen molecule.

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