CTLA4 receptor and uses thereof

Details CTLA4 receptor and uses thereof CTLA4 receptor and uses thereof

1997-07-08

1999-03-23

Walsh, Stephen

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Fusion protein or fusion polypeptide

514 2, 514 12, 4241331, 4241411, 530350, 530866, 530868, 5303871, 435 651, 435 697, 435 72, 935 10, 935 12, A61K 3900

Patent

active

058855793

ABSTRACT:
The invention identifies the CTLA4 receptor as a ligand for the B7 antigen. The complete amino acid sequence encoding human CTLA4 receptor gene is provided. Methods are provided for expressing CTLA4 as an immunoglobulin fusion protein, for preparing hybrid CTLA4 fusion proteins, and for using the soluble fusion proteins, fragments and derivatives thereof, including monoclonal antibodies reactive with B7 and CTLA4, to regulate T cell interactions and immune responses mediated by such interactions.

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