Process for production of prostaglandins D2

Details Process for production of prostaglandins D2 Process for production of prostaglandins D2

1988-09-13

1989-12-12

Gerstl, Robert

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

562503, C07C17700

Patent

active

048869031

ABSTRACT:
The present invention provides a process for the production of PGD.sub.2, wherein 7-hydroxy prostaglandin F.sub.2 .alpha. is treated with thiocarbonyl diimidazole or its analog and subjecting thus treated product to the reaction to deoxidize the hydroxyl group at the 7-position, the reaction to convert the hydroxyl group to a protecting group, and the reaction to oxidize the hydroxyl group at the 11-position, thus giving PGD.sub.2 at a high efficiency.

REFERENCES:
patent: 4013695 (1977-03-01), Lin
patent: 4346228 (1982-08-01), Skuballa et al.
Burton et al., J. C. S. Perkins I, p. 1718 (1977).
Lin et al., J. Org. Chem. 47, 615 (1982).
Suzuki et al., "Synthesis of Prostaglandins D.sub.1 and D.sub.2 Via the 3-Component Coupling Process", 25 Tetrahedron Letters 1383-1386 (1984).

Affiliated with

Also associated with

Rating

Process for production of prostaglandins D2 does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for production of prostaglandins D2, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for production of prostaglandins D2 will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2122511