Phenylbutanol derivatives

Details Phenylbutanol derivatives Phenylbutanol derivatives

1973-02-15

1976-02-03

Winters, Sherman D.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2602475G, 2602936, 26029364, 26029367, 26029368, 26029369, 26029371, 26029376, 26029378, 2602938, 26029383, 2602948D, 260295K, 260296R, 260297R, 424248, 424263, 424267, C07D21152

Patent

active

039364682

ABSTRACT:
Butyrophenone derivatives having excellent psychotropic activity and represented by the formula, ##SPC1##
Wherein A represents a single or double bond linkage; R.sub.1 represents a hydrogen atom or a C.sub.1 - C.sub.4 alkyl group; R.sub.2, which is present only in case A represents a single bond linkage, represents a hydrogen atom, or a hydroxyl, C.sub.1 - C.sub.4 alkyl, or C.sub.1 - C.sub.4 alkoxy group; R.sub.3 represents a hydrogen atom, or a piperidino, pyrrolidino, morpholino, furyl, thienyl, C.sub.1 - C.sub.4 alkylamino, benzylamino, unsubstituted or halogen-substituted phenyl group, etc.; and X represents a hydrogen or halogen atom, or a C.sub.1 - C.sub.4 alkyl, C.sub.1 - C.sub.4 alkoxy, or trifluoromethyl group, can be prepared by reducing a benzoylpropionamide derivative of the formula, ##SPC2##
Wherein A, R.sub.1, R.sub.2, R.sub.3 and X have the same meanings as defined above, to a phenylbutanol derivative of the formula, ##SPC3##

REFERENCES:
patent: 3080372 (1963-03-01), Janssen
patent: 3438991 (1969-04-01), Janssen
patent: 3462444 (1969-08-01), Beckett et al.
Chemical Abstracts 64:5037g (1966) Moehrle.
Intl. J. Neuropharmacol, 1:145-148 (1962) Janssen.
J. Med. & Pharm. Chem. 2:31-45 (1960) Janssen et al.

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