Penicillin antibiotics

Details Penicillin antibiotics Penicillin antibiotics

1975-07-11

1976-02-03

Schwartz, Gerald A.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424271, C07D49970

Patent

active

039364437

ABSTRACT:
The invention provides novel antibiotic compounds which are 6.beta.-acylamidopenam-3-carboxylic acids and non-toxic derivatives thereof, characterized in that the acylamido group has the structure ##EQU1## WHERE R is a hydrogen atom or an organic group and R.sup.a is a hydrogen atom or an acyl group. The compounds are syn isomers or exist as mixtures containing at least 75% of the syn isomer. These antibiotic compounds possess high antibacterial activity against a range of gram positive and gram negative organisms coupled with particularly high stability to .beta.-lactamases produced by various gram negative organisms. The invention is also concerned with the administration of the compounds.

REFERENCES:
ehstrom et al., Acta Chemical Scandanavica 19, (1965), 281-299.
Moses et al., Arkiv for Kemi, Vol. 22, No. 33, pp. 451-467, (1964).

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