Dihydropyridine derivatives and pharmaceutical composition there

Details Dihydropyridine derivatives and pharmaceutical composition there Dihydropyridine derivatives and pharmaceutical composition there

1987-08-20

1989-12-12

Fan, Jane T.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514252, 514255, 514332, 514334, 546321, 546257, 546261, 546262, 546265, 544364, 544365, C07D21186, A61K 31455

Patent

active

048868191

ABSTRACT:
Dihydropyridine derivatives of the formula ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, A, B are defined as in the specification and nontoxic acid-addition salts thereof, have an excellent calcium blocking action (Ca-antagonist), and antihypertensive action, a platelet aggregation-inhibiting action, a phosphodiesterase-inhibiting action and the like, and thus are useful as a medicine, such as a coronary vasocilator, a cerebral hyperkinemic, antihypertensive, thrombosis-preventing or -treating agents, phosphodiesterase-inhibitor or the like. Pharmaceutical compositions and methods of use are also disclosed.

REFERENCES:
patent: 4510310 (1985-04-01), Wehinger
patent: 4595690 (1986-06-01), Clark et al.
patent: 4603135 (1986-07-01), Meguro et al.
patent: 4618607 (1986-10-01), Araki
patent: 4656181 (1987-04-01), Sunkel et al.
patent: 4686222 (1987-08-01), Atkinson
Chem. Abstr., vol. 105, No. 13, 114923v (Clark).
Chem. Abstr., vol. 36, No. 5, 29638a (Bossert).
Chem. Abstr., vol. 106, No. 5, 32844G (Clark); 32841y (Poindexter).

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