Use of volume exclusion agents for the enhancement of in situ hy

Details Use of volume exclusion agents for the enhancement of in situ hy Use of volume exclusion agents for the enhancement of in situ hy

1987-12-09

1989-12-12

Warden, Robert J.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving virus or bacteriophage

435 6, 435 7, 435 21, 435810, 436501, 536 26, 536 27, 536 28, 935 77, 935 78, C12Q 170, C12Q 168, G01N 3353, G01N 33566

Patent

active

048867411

ABSTRACT:
This invention relates to methods for using volume exclusion agents to enhance in situ hybridization rates between short oligonucleotide probes and their target polynucleotides where the cells containing the target polynucleotides are adhered onto a glass substrate. In one aspect, the invention specifically relates to the use of volume exclusion agents to facilitate assay and diagnostic procedures for the detection of a virus, such as human papillomavirus (HPV). In addition, diagnostic kits embracing the above methods are described herein.

REFERENCES:
Wood, W. et al., PNAS, 82: 1585-1588 (1985).
Conner, B., et al., PNAS, 80: 278-282 (1983).
Szabo, P. et al., J. Mol. Biol., 115: 539-563 (1977).

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