Propiophenone derivatives and preparation thereof

Details Propiophenone derivatives and preparation thereof Propiophenone derivatives and preparation thereof

1976-03-11

1980-01-01

Milestone, Norma S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

424267, C07D29510

Patent

active

041818032

ABSTRACT:
New propiophenone derivatives prepared by the reaction of propiophenone, formaldehyde and piperidine, as well as pharmacologically acceptable acid-addition salts thereof are provided, which possess improved pharmacological activities such as anti-tramorine and anti-nicotine activities superior to those of the known analoguous compound. The new compounds are useful for the therapeutic treatment of human patient suffering from pathological muscular contracture, spastic paralysis due to cerebral apoplexy, spinal and cerebral palsies and the like.

REFERENCES:
patent: 2771391 (1956-11-01), Bockstahler
Ueda et al., Chemical Abstracts, vol. 56 (1962) 12863a.
Name Reactions in Organic Chemistry (1954) Surrey, pp. 118-120.
Porszasz et al., Chemical Abstracts, vol. 55 (1961) 13637a.
Kato et al., Jour. Pharmacol. Exptl. Therapeutics, vol. 149, No. 1 (1965), pp. 131-137.

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