Process for preparing 2,4-diamino-5-(substituted benzyl)-pyrimid

Details Process for preparing 2,4-diamino-5-(substituted benzyl)-pyrimid Process for preparing 2,4-diamino-5-(substituted benzyl)-pyrimid

1976-11-17

1978-09-19

Coughlan, Jr., Paul M.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

544325, C07D23948, C07D40506

Patent

active

041156501

ABSTRACT:
2,4-Diaminopyrimidines bearing a substituted benzyl group in position-1 are prepared from the correspondingly substituted .alpha.-alkoxymethylcinnamonitrile by treatment of the latter with an alkali metal alkoxide in mono-methyl ether of ethylene glycol and subsequently reacting the resulting reaction mixture with guanidine.

REFERENCES:
patent: 3940393 (1976-02-01), Greenspan et al.
patent: 3992379 (1976-11-01), Liebenow et al.

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