Process for 3-chloro cephalosporins

Details Process for 3-chloro cephalosporins Process for 3-chloro cephalosporins

1977-08-08

1978-09-19

Rizzo, Nicholas S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

424246, C07D50104

Patent

active

041156439

ABSTRACT:
7-Acylamido-3-hydroxy-3-cephem-4-carboxylic acid ester sulfoxides are chlorinated and reduced in a single step process with phosphorus trichloride in dimethylformamide to provide 7-acylamido-3-chloro-3-cephem-4-carboxylic acid ester sulfides.

REFERENCES:
patent: 3641014 (1972-02-01), Murphy et al.
patent: 3925372 (1975-12-01), Chauvette
patent: 3962227 (1976-06-01), Chauvette

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