Synthetic heat-stable enterotoxin polypeptide of Escherichia col

Details Synthetic heat-stable enterotoxin polypeptide of Escherichia col Synthetic heat-stable enterotoxin polypeptide of Escherichia col

1983-12-12

1989-12-12

Phillips, Delbert R.

Drug, bio-affecting and body treating compositions

Lymphokine

530327, 530326, 530324, 530806, A61K 39108, C07K 710

Patent

active

048866636

ABSTRACT:
A synthetic polypeptide having at least about 10% of the immunological activity of biologic heat-stable enterotoxin of E. coli. The synthetic polypeptide includes at least 14 amino acids in the sequence, from amino-terminus to carboxy-terminus, represented by the formula: CysCysGluLeuCysCysTyr-(Asn)ProAlaCysAla(Thr)GlyCysAsn(Tyr) wherein the amino acid in parentheses may replace the immediately preceding amino acid residue, and at least one intramolecular disulfide bond formed between the Cys residues. The Cys residues that are not part of the intramolecular disulfide bond can be replaced by other amino acid residues or be bonded to substituent moieties. The polypeptides can be a monomeric or multimeric material containing an intramolecular, intrapolypeptide and/or an intramolecular, interpolypeptide cystine disulfide bond.

REFERENCES:
patent: 4314993 (1982-02-01), Wijnendaele
patent: 4411888 (1983-10-01), Klipstein et al.
patent: 4499080 (1985-02-01), Duflot et al.
Infect. Immun., 37, 550-557 (1982).
Proc. Nat'l Acad. Sci., 77, 4011-4015 (1980).
J. Biol. Chem., vol. 256, (1981) 7744-7746.
Stimulus-Secretion Coupling in the Gastrointestinal Tract, 10.
Infection and Immunity (1980) 91-97, vol. 29.
The J. Biol. Chem. 254, (1979) 9254-9261.
Proc. Nat'l. Acad. Sci. 76, (1979) 4832-4836.
The Journal of Infectious Diseases 141, (1980) 64-70.
Med. Hypotheses 5, 347-349, 1979.
Infection and Immun., 1983, 269-275, vol. 42.
Biochem. and Biophys. Res. Commun., 1983, vol. 112, pp. 320-326.
J. Gen. Microbiol. (1982) 128, 2081-2096.
J. Bacteriology, 1983, 728-733, vol. 155.
Gastroenterology 78, 1545-1553, 1980.
Wijnendaele et al., Zbl. Vet. Med. B, 29:441-450 (1980).
Duflot et al., Proceedings, European Peptide Symposium, Aug. 29, 1982.
M. P. Stevens, Polymer Chemistry an Introduction, Addison-Wesley Publishing Co., Inc., Reading, MA (1975), pp. 3, 8 and 9.

Affiliated with

Also associated with

Rating

Synthetic heat-stable enterotoxin polypeptide of Escherichia col does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Synthetic heat-stable enterotoxin polypeptide of Escherichia col, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Synthetic heat-stable enterotoxin polypeptide of Escherichia col will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2120786