Non-invasive measurement of blood PH

Details Non-invasive measurement of blood PH Non-invasive measurement of blood PH

1997-06-09

1999-03-23

Hindenburg, Max

Surgery

Diagnostic testing

Measuring or detecting nonradioactive constituent of body...

356 39, A61B 500

Patent

active

058852123

ABSTRACT:
Methods and apparatus are provided for non-invasively determining blood pH by a multivariate analysis technique, such as classical least squares (CLS), partial least squares (PLS), or principal components regression (PCR). The technique employs at least one spectral factor based on the difference in the spectrum of a hemoglobin fraction (e.g., oxyhemoglobin) at two different pH's (e.g., pH 7.2 and pH 7.8). The spectral factor is preferably evaluated over the wavelength range of 520-680 nm.

REFERENCES:
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patent: 5435309 (1995-07-01), Thomas et al.
Brunzel, U. et al. "pH-Dependent Absorption in the B and Q Bands of Oxyhemoblobin and Chemically Modified Oxyhemoglobin (BME) at Low CL Concentrations" Biophysical Journal, vol. 49, (1986) 1069-1076.
Wimberley P., et al. "Effect of pH on the Absorption Spectrum of Human Oxyhemoglobin: a Potential Source of Error in Measuring the Oxygen Saturation of Hemoglobin" Clinical Chemistry, vol. 34, No. 4 (1988) 750-754.
Alam, M.K. et al., "Near-infrared spectroscopy of lysed blood: pH effects", Proceedings SPIE, vol. 2680, Ultrasensitive biomedical diagnostics, San Jose, CA, (1996) pp. 146-155.
Haaland et al., "Partial Least-Squares Methods for Spectral Analyses. 1. Relation to Other Quantitative Calibration Methods and the Extraction of Qualitative Information", Anal. Chem., 60 (1988) pp. 1193-1202.
Owen, "Quantitative UV-Visible Analysis in the Presence of Scattering", Hewlett-Packard Application Note, publication 12-5963-3937E, 1995, pp. 0-7 .

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