Tetrahydrocarbazole derivatives and pharmaceutical compositions

Details Tetrahydrocarbazole derivatives and pharmaceutical compositions Tetrahydrocarbazole derivatives and pharmaceutical compositions

1986-08-22

1987-10-06

Ramsuer, Robert W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514339, 546270, 546272, A61K 3144, C07D40106, C07D491056

Patent

active

046983511

ABSTRACT:
Tetrahydrocarbazole derivatives of the general formula I ##STR1## in which Thc is a 1,2,3,4-tetrahydro-3-carbazolyl radical which can be substituted once or twice by alkyl, O-alkyl, S-alkyl, SO-alkyl, SO.sub.2 -alkyl, OH, F, Cl, Br, CF.sub.3 and/or CN or by a methylenedioxy group, the two radicals Y are each H or together are a C-C bond, one radical Z is Ar and the other radical Z is H, A is --CH.sub.2 -- or --CH.sub.2 CH.sub.2 -- and Ar is a phenyl group which is unsubstituted or substituted once or twice by alkyl, O-alkyl, S-alkyl, SO-alkyl, SO.sub.2 -alkyl, OH, F, Cl, Br, CF.sub.3 and/or CN or by a methylenedioxy group, or is a 2- or 3-thienyl radical, and in which the alkyl groups each have 1-4 C atoms, and their physiologically acceptable acid addition salts have effects on the central nervous system.

REFERENCES:
patent: 3634420 (1972-01-01), Littell et al.
patent: 3740404 (1973-06-01), Littell et al.

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