Pyrazinone N-oxide nucleosides and analogs thereof

Details Pyrazinone N-oxide nucleosides and analogs thereof Pyrazinone N-oxide nucleosides and analogs thereof

1991-05-30

1993-03-09

Tsang, Cecilia

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514255, 544405, 544408, A61K 31495, C07D24102

Patent

active

051927640

ABSTRACT:
This invention relates to nucleoside and acyclo analogs containing 5- or 6-substituted 2-pyrazinone-4-N-oxide. These compounds are useful for treating various conditions including viral infections, cancer, fungal infections, bacterial infections, microbial infections and related disease states. This invention also relates to pharmaceutical formulations containing these compounds. In addition, this invention relates to methods of treating the above-described conditions in animals and in particular, humans.

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This work is supported by the National Cancer Institute, National Institutes of Health, grant numbers CA-44358 and CA-06695 and National Institute of Arthritis and Infectious Diseases, National Institutes of Health, grant number AI-29430. The government retains certain rights in the invention.

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