Pyrimidinedione derivatives and antiarrythmic agents containing

Details Pyrimidinedione derivatives and antiarrythmic agents containing Pyrimidinedione derivatives and antiarrythmic agents containing

1992-08-12

1994-05-03

Shah, Mukund J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514274, 544311, 544312, 544314, A61K 31505, C07D23910

Patent

active

053088484

ABSTRACT:
A pyrimidinedione derivative compound has a basic backbone in which a phenyl group part and a pyrimidinedione part are linked by a linking structure comprising an alkyl chain containing two nitrogen atoms. This linking structure is represented by ##STR1## [wherein A is --(CH.sub.2).sub.n --, --CO-- or --O--(CH.sub.2).sub.m --; each of R.sup.1 and R.sup.2 is independently a hydrogen atom or a lower alkyl group which may be substituted by a hydroxyl group, or R.sup.1 and R.sup.2 may be so linked with each other as to make an alkylene chain and thus form a heterocyclic structure; R.sup.5 is a halogen atom, a hydroxyl group, a lower alkyloxycarbonyl group, a lower alkyloxy group which may be substituted by a lower alkyloxy group, or a lower alkyl group which may be substituted by a hydroxyl group, or R.sup.5 may be so linked with R.sup.1 as to make an alkylene chain and thus form a heterocyclic structure; n is 0, 1, 2 or 3 (when R.sup.5 is the hydroxyl group, n.noteq.0); m is 0, 1, 2 or 3; and k is 0, 1, 2 or 3 (however, a compound in which A is --O--(CH.sub.2).sub.m -- and R.sup.5 is the hydroxyl group is excluded from the pyrimidinedione derivative)]. The pyrimidinedione derivative and its acid addition salt are useful for a medical treatment of cardiac arrhythmias.

REFERENCES:
patent: 4216314 (1980-08-01), Raabe et al.
patent: 5008267 (1991-04-01), Katakami et al.
Kataue et al., Chemical Abs., 113(5), 40725, 1989.
Mitsui Toatsu, Chemical Abs., 103(1), 6363n, 1984.
Cassela, Chemical Abs., 90(15), 121639, 1978.
Raabe et al., Chemical Abs., 90(15), 121636, 1978.
The Pharmacological Basis of Therapeutics; Goodman and Gillman, p. 840, 1990.
Cardiova. Pharmacology, Second Edition, Lucchesi et al., p. 329, 1984.
Drugs, 35:286-319, 1988, p. 286.
Goldberger et al., International Journal of Cardiology, vol. 13, pp. 47-55, 1986.
Lynch et al., Journal of Cardiovascular Pharmacology, vol. 6, pp. 1132-1141, 1984.
Mitsunobu, Synthesis, pp. 1-28, 1981.
Platou et al., Journal of Cardiovascular Pharmacology, vol. 8, pp. 459-465, 1986.

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