Treatment of endotoxin-associated shock and prevention thereof u

Details Treatment of endotoxin-associated shock and prevention thereof u Treatment of endotoxin-associated shock and prevention thereof u

1992-12-14

1994-05-03

Wityshyn, Michael G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 8, 514 21, A61K 3702

Patent

active

053088344

ABSTRACT:
The present invention provides a method for preventing endotoxin-associated shock in a subject which comprises administering to the subject an amount of a BPI protein effective to bind to endotoxin so as to prevent endotoxin associated shock in the subject. This invention further provides a method for treating a subject suffering from endotoxin-associated shock which comprises administering to the subject an amount of a BPI protein effective to bind endotoxin so as to treat the subject suffering from endotoxin-associated shock.

REFERENCES:
P. Elsbach, et al. (1988) Bacteria-Host Cell Interaction, pp. 47-60.
P. Gray, et al. (1988) Clinical Research, 36(3):620A.
J. Weiss, et al. (1982) The American Society of Clinical Investigation, Inc. 69:959.
J. Weiss, et al. (1985) The American Society of Clinical Investigation, Inc. 76:206.
J. Weiss, et al. (1982) Infection and Immunity, 38:1149-1153.
W. M. Shafer, et al. (1984) Infection and Immunity, 45:29-35.
C. J. Hovde, et al. (1986) Infection and Immunity, 54:142-148.
M. M. Farley, et al. (1987) Infection and Immunity, 55:1536-1539.
G. I. Veld, et al. (1988) Infection and Immunity, 56:1203-1208.
M. M. Farley, et al. (1988) Infection and Immunity, 56:1589-1592.
J. Weiss, et al. (1985) ASCI Metabolism, 33(2):567A.

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